Endocrine Abstracts

Background: Craniopharyngiomas are rare, relatively benign, slowly growing intracranial tumors originating in pituitary gland embryonic tissue. They may present at any age, with two peaks of occurrence in children and in older adults. Clinical symptoms are the result of mass effects. Treatment options include surgery, radio- and chemotherapy and unfortunately are connected with a high ratio of postoperative pituitary insufficiency.Aim: To present the lon...

Introduction: Observed increasing frequencies of asymptomatic or oligosymptomatic PHP cases may increase the rate of false negative imaging results.Aim: To determine the level of PTH and calcium at which an enlarged parathyroid gland can be detected by parathyroid SPECT/CT.Material and methods: A retrospective analysis of 117 patients diagnosed with PHP (100 females and 17 males, aged 16–88 years) was performed. In each patien...

Background: The human leukocyte antigen (HLA) cluster is a genetic region that has been associated with multiple autoimmune disorders, also with autoimmune thyroid diseases. Plenty attempts to establish the significance of class II HLA-DR in Hashimoto’s thyroiditis (HT) development were undertaken in the past; however, reports are rather divergent. This might be caused by different criteria used to diagnose HT. There is however an alternative hypothesis, according to whic...

Goiter frequency (GF) in schoolchildren and urinary iodine concentration (UIC) in an appropriately large population sample are iodine nutrition (IN) best indicators. GF in mildly iodine deficient areas should be assessed ultrasonographically, as palpation sensitivity in such cases is low.Aim: To assess thyroid volume reference values as IN marker in population with recently introduced obligatory iodine prophylaxis (OIP).Material an...

Therapy with labeled somatostatin analogues is the modern approach to patients with disseminated or unresectable NETs expressing somatostatin receptors (SSTR). Octreotate is the somatostatin analogue with high affinity to SSTR type 2, most commonly present in NETs. The aim of the study was to assess the efficacy and toxicity of peptide receptor radionuclide therapy (PRRT) with the use of 90Y labelled Tyr3-octreotate, (90Y-DOTATATE) in NETs....

The pheochromocytoma (PH) diagnosis is often very difficult, particularly in asymptomatic or oligosymptomatic patients. Every subject with adrenal tumor should be screened for PH, although many factors may interfere with biochemical evaluation. The false positive testing for PH may result in unnecessary surgical treatment.Methods: Retrospective analysis of 45 patients after laparoscopic adrenalectomy due to suspicion of PH (based on biochemical testing) ...

Neuroendocrine tumours (NETs) are rare neoplasm arising from dispersed endocrine system. Their incidence is estimated to be five cases per 100 000 population, although the true incidence may be higher as the consequence of often oligosymptomatic course of disease and indolent behaviour of NETs. The most typical localization of NETs is gastrointestinal tract and bronchi. However they may develop in every organ of the body containing neuroendocrine cells. The diagnosis of NET is...

Aim: Aim of the study was to assess the effectiveness of the structured lifestyle intervention in diabetes type 2 high risk people.Methods: The De-Plan Project participants were selected based on FINDRISK over 14. Exclusion criteria were known or OGTT diabetes. Intervention completed by 175 participants consisted of 10 group sessions on lifestyle changes, diet and physical activity education, and 6 telephone motivation sessions and voluntary physical act...

The pattern of SSTRs expression in neuroendocrine neoplasms determines the possibility of the detection of the primary tumour and distant metastases, the application of radio-guided surgery (RGS) and the outcome of the treatment with itrium or lutetium labeled somatostatin analogues. The frequency and expression pattern of each subtype of SSTRs not only vary considerably in different NET but also in each patient.The aim of the study was to assess the SST...

In the 1980 s the discovery of expression of somatostatin receptors on NET cells made the use of somatostatin analogues in diagnosis and therapy possible.The aim: Of the study was to assess response of targeted radio-nuclide therapy with radio-labelled somatostatin analogue 90Y-[DOTA0,D-Phe1,Tyr3]-octreotate (DOTATATE) in treatment of disseminated NETs.Material and methods: 12 patients (a...